한국균학회지 (The Korean Journal of Mycology)

  • 제8권1호
  • /
  • Pages.69-71
  • /
  • 1980
  • /
  • 0253-651X(pISSN)
  • /
  • 2383-5249(eISSN)
한국균학회 (The Korean Society of Mycology)
권호 표지

염산바캄피실린의 역가 검정법에 관한 연구

A Study on the Microbiological Assay of Bacampicillin Hydrochloride

  • 정경수 (서울대학교 약학대학 미생물약품화학교실) ;
  • 김영준 (서울대학교 약학대학 미생물약품화학교실) ;
  • 이송애 (서울대학교 약학대학 미생물약품화학교실) ;
  • 김병각 (서울대학교 약학대학 미생물약품화학교실)
  • Chung, Kyeong-Soo (Department of Microbial Chemistry, College of Pharmacy Seoul National University) ;
  • Kim, Young-Jun (Department of Microbial Chemistry, College of Pharmacy Seoul National University) ;
  • Lee, Song-Ae (Department of Microbial Chemistry, College of Pharmacy Seoul National University) ;
  • Kim, Byung-Kak (Department of Microbial Chemistry, College of Pharmacy Seoul National University)
  • 발행 : 1980.03.30
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초록

To establish a competent method of microbiological assay for bacampicillin, one of new semi-synthetic derivatives of ${\beta}-lactam$ antibiotics, a comparison was carried out between different conditions for hydrolysis of bacampicillin into ampicillin which was then subjected to cylinder plate method. The results showed that the use of carboxylic ester hydrolase in vitro as a pretreatment of it in either pH value 6 or 8 was feasible and that the cylinder plate method with Sarcina lutea was adequate for potency estimation.

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