Effect of Penicillin G on the Diuretic Action of Furosemide in Rabbit

Penicillin G 주입이 Furosemide 이뇨작용에 미치는 영향

  • Kim I.S. (Department of Pharmacology, Catholic Medical College) ;
  • Lee S.B. (Department of Pharmacology, Catholic Medical College) ;
  • Cho K.C. (Department of Pharmacology, Catholic Medical College)
  • 김인순 (가톨릭의대 약리학교실) ;
  • 이상복 (가톨릭의대 약리학교실) ;
  • 조규철 (가톨릭의대 약리학교실)
  • Published : 1980.12.01

Abstract

The influence of penicillin G infusion(7.5 units/min/kg) on the diuretic action of furosemide$(250{\mu}g/kg)$ in rabbits was studied to investigate the drug interaction between penicillin G and furosemide. The results were as follows: 1) There was no significant change in renal function in the penicillin G infused rabbits compared with the normal ratbit. 2) In comparison with the control group, a significant increase in ${\triangle}U_{flow},\;{\triangle}U_{Na}V,\;{\triangle}U-kV\;and{\triangle}U_{cl}V$ was noted by 30 minutes following the administration of furosemide in the penicillin G infused group. There was no significant difference in ${\triangle}C_{In},\;{\triangle}C_{PAH}$ between the two groups and ${\triangle}Na^+$ reabsorption rate was significantly decreased in the latter. The potentiating effect of penicillin G on the diuretic action of furosemide should be due to the increased luminal concentration of free form of furosemide, and it may be related to the competitive inhibition of plasma protein binding between the two drugs.

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