Studies on the Determination of Hyoscine-N-butylbromide by ORD and CD(I)

ORD 및 CD에 의한 Tropane Alkaloid의 정량에 관한연구(I) - Hyoscine-N-butylbromide의 정량

The ORD and CD for hyoscine-N-butylbromide present curves of negative Cotton effect in 190-250nm region. The values of .alpha./sub 232/ .alpha./sub 208/, vertical bar .alpha./sub 232/ vertical bar + vertical bar .alpha./sub 208/ and .theta./sub 221.5/ have linearities in the range of lower concentration (hyoscine-N-butylbromide 0.01-0.1w/v%). It is possible to determine the optical purity of hyoseine-N-butylbromide by using these linearities. This experiment is extremely simple and less time-consuming than other methods for estimating optical purity.