YAKHAK HOEJI (약학회지)

The Pharmaceutical Society of Korea (대한약학회)
권호 표지

Benorylate Interaction with Ethoxybenzamide and Lorazepam

Benorylate와 Ethoxybenzamide 밍 Lorazepam 과의 상호작용

  • Published : 1979.03.01
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Abstract

Benorylate and ethoxybenzamide have been used alone or in combination as an analgesic, antipyretic and antiinflammatory agent. We investigated the significance of the differences of analgesic activities between single and concurrent administration of benorylate and ethoxybenzamide and lorazepam in mice and also antipyretic activity between single and concurrent administration of benorylate and ethoxybenzamide in rats. 1). Concurrent administration of each half dose of benorylate and ethoxybenamide showed much inhibiting effect on the acetic acid-induced writhing syndrome of mice than the above drug alone, and the some increased analgesic response by hot plate method. 2). The synergistic and analgesic effect of combined administration of benorylate and lorazepam was found to be significant. 3). Antipyretic effect of half-dose combined administration of benorylate and ethoxybenzamide on the rat pyrexia induced by yeast(s.c.) and T.T.G. (i.v.) was shown to be similar to the effect of each drug.

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References

  1. British Patent Specificeation No.1101747 A.Robertson
  2. Arzt. Prax. v.21 W.Reiter(et al.)
  3. Clin. Triasls J. v.7 L.S.Bain(et al.)
  4. Clin. Trials J. v.7 N.Cardoe
  5. Clin. Trials J. v.8 D.I.Haslock(et al.)
  6. Curr. Therap. Res. v.14 M.Franke(et al.)
  7. Brit. Med. J. v.2 D.L.Beales(et al.)
  8. Z. Rheumatol. v.33 L. May(et al.)
  9. Therapie v.23 J. Weill(et al.)
  10. Bruxelles-Medical v.50 F.Alexander(et al.)
  11. Ther. Umsch. v.28 M.Vest(et al.)
  12. Therapie v.23 C.Vialatel(et al.)
  13. Clin. Trials J. v.8 G.Hart(et al.)
  14. Therapie v.23 I.Rosner(et al.)
  15. Proc. Intern. Congr. Rheum. P.A.Nicholson
  16. Arzneim-Forsch. v.19 E.Liss;G.Palme
  17. Arzneim-Forsch. v.25 E.Liss;A.Robertson
  18. Xenobiotica v.2 A.Robertson(et al.)
  19. Arc. Int. Pharmacodyn. v.219 H.Khalili Varastch(et al.)
  20. 藥劑學會誌 v.1 金吉香(등)
  21. 同德女大論文集 v.1 金尙敏(등)
  22. Ann. Rev. Pharmacol. v.14 S.H.Ferreira(et al.)
  23. Arch. Int. Pharmacodyn. Ther. v.149 F.Guzman;C.Braun
  24. Nature v.184 C.V.Winder
  25. Nature v.152 R.K.S.Lim(et al.)
  26. Fed. Proc. Fed. Am. Soc Exp. Biol. v.36 M.E.Ellis(et al.)
  27. Ars. Med. v.29 DE Thibault DE Boesinghe L.(et al.)
  28. J. Pharmacol. Exp. Ther. v.136 D.Meta(et al.)
  29. Brit. J. Pharmcol. B.A.Whittle
  30. J. Pharmcol. Exper. Therap. v.80 G.Woolfe;A.D.MacDonald
  31. 日藥理誌 v.61 瀧野勝行
  32. J. Pharmacol. Exper. Therap. v.133 C.V.Winder(et al.)
  33. Arch. Int. Pharmacodyn. Ther. v.204 M.R.Fenessy(et al.)
  34. Indian J. Med. Res. v.56 P.P.Chawla
  35. Federtion Proc. v.18 R.Koster(et al.)
  36. 日學理誌 v.67 阿部武誌 (등)
  37. Arzneim-Forsch. v.25 C.J.E.Niemegeers(et al.)