생약학회지 (Korean Journal of Pharmacognosy)
- 제10권2호
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- Pages.73-77
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- 1979
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- 0253-3073(pISSN)
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- 2288-9299(eISSN)
Phytolaccosides의 소염작용(消炎作用)
Antiinflammatory Action of Phytolaccosides
- Shin, Kuk-Hyun (Natural Products Research Institute, Seoul National University) ;
- Woo, Won-Sick (Natural Products Research Institute, Seoul National University) ;
- Lee, Chung-Kyu (Natural Products Research Institute, Seoul National University)
- 발행 : 1979.06.15
초록
Antiinflammatory action of phytolaccosides B and E isolated from the roots of Phytolacca americana was investigated and compared with that of aescin. Phytolaccoside B, when it was administered intravenously, exerted a potent inhibitory effect on the transudation caused by absorptive sponge pellet implanted s.c. in rats and on carrageenin induced edema in rats. Phytolaccoside E showed a weaker action than Phytolaccoside B did. Hemolytic potency of the saponins was decreased in the order of aescin, phytolaccosides B and E showing a same tendency as in antiinflammatory action. The experimental result suggests that the mode of action of phytolaccosides is the same as that of aescin.
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