Comparative Antimicrobial Susceptibility by the Methods of Test

검사방법(檢査方法)에 따르는 항균제감수성(抗菌劑感受性)의 비교(比較)

The difference in antimicrobial susceptibility of multiply drug-resistant Salmonella typhi by the methods of test was tested against chloramphenicol(Cm), tetracycline(Tc), ampicillin(Ap), kanamycin(Km), and rifampicin(Rif), and the results were compared by the minimum inhibitory concentration(MIC). No appreciable difference was noted between MICs of Cm, Tc, and Rif measured by agar plate dilution(plate) method and broth dilution(broth) method. However, MICs of Km to about a half of test strains were 4 to 8-fold higher by broth method than plate method, and MICs of Ap by broth method were also a little higher than plate method in some strains. Cm and Rif were bacteriostatic rather than bactericidal to the most of test strains in high concentrations. Tc, Ap and Km were exclusively bactericidal to the test strains.

항균제내성(抗菌劑耐性)인 Salmonella typhi를 공시(供試)하여 chloramphenicol(Cm), tetracycline(Tc), ampicillin(Ap), kanamycin(Km) 및 rifampicin(Rif)의 항균작용(抗菌作用)을 한천평판희석법(寒天平板稀釋法)(평판법(平板法))과 broth 희석법(稀釋法)(broth법(法))으로 비교(比較)하였다. 공시균(供試菌)의 최소발육저지농도(最少發育沮止濃度)(MIC)를 보면 Cm, Tc 및 Rif에 있어서는 평판법(平板法)과 broth법(法) 사이에 유의(留意)할만한 차이(差異)는 없었으나 Km에 있어서는 broth법(法)의 MIC가 평판법(平板法)보다 높은 것이 약(約) 반수(半數)있었고 Ap에 있어서도 소수(少數) 있었다. Cm과 Rif는 대부분(大部分)의 공시균(供試菌)에 대(對)하여 정균적(靜菌的)으로 작용(作用)하였으나 Tc, Ap 및 Km은 살균적(殺菌的)으로 작용(作用)하였고 그 작용(作用)은 균주(菌株)에 따라 차이(差異)가 있었다.