Journal of Pharmaceutical Investigation
- Volume 8 Issue 1
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- Pages.27-36
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- 1978
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- 2093-5552(pISSN)
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- 2093-6214(eISSN)
Pharmaceutical Studies on Anti-inflammatory Enzyme Preparations
소염효소제(消炎酵素劑)의 약제학적(藥劑學的) 연구(硏究)
- Lee, Kang-Choon (Central Research Laboratory, Dong-A Pharm. Co., Ltd) ;
- Yang, Joong-Ik (Central Research Laboratory, Dong-A Pharm. Co., Ltd) ;
- Min, Shin-Hong (Central Research Laboratory, Dong-A Pharm. Co., Ltd) ;
- Rhee, Shang-Hi (Central Research Laboratory, Dong-A Pharm. Co., Ltd) ;
- Kim, Yong-Bae (Central Research Laboratory, Dong-A Pharm. Co., Ltd)
- 이강춘 (동아제약(주), 중앙연구소) ;
- 양중익 (동아제약(주), 중앙연구소) ;
- 민신홍 (동아제약(주), 중앙연구소) ;
- 이상의 (동아제약(주), 중앙연구소) ;
- 김용배 (동아제약(주), 중앙연구소)
- Published : 1978.03.20
Abstract
Spherical granules of anti-inflammatory enzyme were prepared by mixer granulation and the recovery rate of enzyme activity by processing was compared with tablet ones. In the enteric granule coating .processing, the effect of the amount of coating solution and the conentration of fatty alcohol on disintegration and stabilities on the accelerated conditions were also studied. Being prepared in non-pressure and non-aqueous condition, spherical granules of enzyme made better recovery of enzme activity than tablet ones by 10 times. Combined processing of both mixer granulation and enteric granule film coating provided the noble enteric coated granules, in the sense of disintegration and stabilities, was obtained from using 0.125% fatty alcohol in coating solution.
Keywords