The Korean Journal of Physiology
- Volume 11 Issue 1
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- Pages.45-50
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- 1977
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- 0300-4015(pISSN)
Influence of cingulate cortical ablation and vagotomy upon gastric ulceration in rats
흰쥐의 위궤양 발생에 미치는 대상회전 제거 및 미주신경 절단의 영향
- Park, Hyoung-Jin (Department of Physiology, Catholic Medical College) ;
- Kang, Sook-Hee (Department of Physiology, Catholic Medical College) ;
- Jo, Yang-Hyeok (Department of Physiology, Catholic Medical College) ;
- Kim, Chul (Department of Physiology, Catholic Medical College)
- Published : 1977.06.30
Abstract
This study was undertaken to investigate the effect of cingulate cortical ablation upon gastric ulceration, and the pathway through which cingulate cortex exerts the effect. 56 female rats were divided equally into cingulate (cingulate cortical ablation), cingulate-vagal (cingulate cortical ablation and vagotomy), normal control and vagal (vagotomy) groups. Cingulate cortex was ablated through a slit-shaped opening (1 mm in width, 13 mm in length) which was made symmetrically on both sides of, and parallel to, the sagittal suture by removing a bone flap from parietal and frontal bones on each side. Vagus nerves on both sides were transected around the distal end of the esophagus. In the normal control animals, surgical intervention ended with scalp incision. All rats were kept without restraint or food deprivation for 3 weeks after surgery. The stomach of each rat was inflated with 7 ml of physiological saline and then removed under deep anesthesia. The mucosal surface was examined under dissecting microscope for the location, shape and number of ulcers, and then enlarged photograph
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