대한약리학회지 (The Korean Journal of Pharmacology)
- 제13권1호
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- Pages.29-33
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- 1977
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- 0377-9459(pISSN)
고장수액의 위내 주입으로 인한 취외분비의 변동
Effects of Intragastric Hypertonic Solution on Pancreatic Exocrine Secretion
- Cho, T.S. (Department of Pharmacology, Yonsei University College of Medicine Seoul, Korea) ;
- Kim, W.J. (Department of Pharmacology, Yonsei University College of Medicine Seoul, Korea) ;
- Hong, S.S. (Department of Pharmacology, Yonsei University College of Medicine Seoul, Korea)
- 발행 : 1977.06.01
초록
Effects of 50% glucose solution on pancreatic exocrine function were studied in rat, rabbit and cat. The alterations during the resting state, the continuous intravenous infusion of secretin and the infusion of secretin with CCK-PZ were determined. 1) No change of pancreatic secretion in rat was observed by intragastric administration of the hypertonic glucose solution. 2) Intragastric administration of the hypertonic glucose solution in rabbit produced the inhibitory effect on pancreatic secretion during secretion infusion. 3) While secretin with CCK-PZ were infused continuously, intragastric administration of the hypertonic glucose solution revealed the marked inhibitory effect on pancrcreatic secretion in cat. Oral administration of the hypertonic glucose solution produced no significant inhibition in the resting gland but markedly depressed the pancreatic flow and enzyme concentration in the secretin or CCK-PZ stimulated gland. It is felt that the inhibitory response of exocrine pancreas induced by intragastric hytertonic glucose solution is resulted in interaction between secretory hormone and gastric mucosal factor possibly enteroglucagon.
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