대한약리학회지 (The Korean Journal of Pharmacology)
- 제13권1호
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- Pages.7-12
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- 1977
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- 0377-9459(pISSN)
저온관류 흰쥐 심방표본의 Catecholamine 및 Ouabain 반응에 관한 연구
Effects of catecholamine and ouabain on isolated rat atrium suspended in hypothermic bath
초록
Recently several reports have claimed that the bath temperature changes, such as lower bath temperature, produce supersensitivity on the positive chronotropic effect of catecholamine in cat, mouse and guinea pig atria. However, others showed controversial results against temperature-dependent supersensitivity. Similarly, the inotropic effect of ouabain is diminished in febrile state, however some investigators indicated that cardiac glycoside showed less toxicities and less effects in hypothermic condition. In this study, the effects of norepinephrine and epinephrine on inotropy and chronotropy in isolated rat atria was investigated by changing the temperature of bath (
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