대한핵의학회지 (The Korean Journal of Nuclear Medicine)
- 제10권1호
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- Pages.21-34
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- 1976
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- 1225-6714(pISSN)
철결핍성빈혈(鐵缺乏性貧血)에서 Cobalt($^{58}Co$ )배설율검사(排泄率檢査)의 진단적(診斷的) 가치(價値)
Diagnostic Value of the Cobalt($^{58}Co$ ) Excretion Test in Iron Deficiency Anemia
- 신현정 (서울대학교 의과대학 내과학교실) ;
- 홍기석 (서울대학교 의과대학 내과학교실) ;
- 조경삼 (서울대학교 의과대학 내과학교실) ;
- 송인경 (서울대학교 의과대학 내과학교실) ;
- 고창순 (서울대학교 의과대학 내과학교실) ;
- 이문호 (서울대학교 의과대학 내과학교실)
- Sihn, Hyun-Chung (Department of Internal Medicine, College of Medicine, Seoul National University) ;
- Hong, Kee-Suck (Department of Internal Medicine, College of Medicine, Seoul National University) ;
- Cho, Kyung-Sam (Department of Internal Medicine, College of Medicine, Seoul National University) ;
- Song, In-Kyung (Department of Internal Medicine, College of Medicine, Seoul National University) ;
- Koh, Chang-Soon (Department of Internal Medicine, College of Medicine, Seoul National University) ;
- Lee, Mun-Ho (Department of Internal Medicine, College of Medicine, Seoul National University)
- 발행 : 1976.06.05
초록
The diagnosis of iron deficiency rests upon the correct evaluation of body iron stores. Morphological interpretation of blood film and the red cell indices are not reliable and often absent in mild iron deficiency. Serum iron levels and iron-binding capacity are more sensitive indices of iron deficiency, but they are often normal in iron depletion and mild iron deficiency anemia. They are also subject to many variables which may introduce substantial errors and influenced by many pathologic and physiologic states. Examination of the bone marrow aspirate for stainable iron has been regarded as one of the most sensitive and reliable diagnostic method for detecting iron deficiency, but this also has limitations. Thus, there is still need for a more practical, but sensitive and reliable substitute as a screening test of iron deficiency. Pollack et al. (1965) observed that the intestinal absorption of cobalt was raised in iron-deficient rats and Valberg et al. (1969) found that cobalt absorption was elevated in patients with iron deficiency. A direct correlation was demonstrated between the amounts of radioiron and radiocobalt absorbed. Unlike iron, excess cobalt was excreted by the kidney, the percentage of radioactivity in the urine being directly related to the percentage absorbed from the gastrointestinal tract. Recently a test based on the urinary excretion of an oral dose of
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