The Journal of Internal Korean Medicine (대한한방내과학회지)

The Society of Internal Korean Medicine (대한한방내과학회)
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EFFECT OF DIETARY GINSENG ON THE ACTIVITIES OF SERUM GLUTAMIC-PYRUVIC AND GLUTAMIC-OXALOACETIC TRANSAMINASES

식이성(食餌性) 인삼(人蔘)이 혈청(血淸) GOT 및 GPT 활성(活性)에 미치는 영향(影響)

  • Published : 1976.04.30
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Abstract

A chronical intake of Substantial amount of alcohol would disrupt anormal function of liver if not develop liver diseases in relatively short period. In order to out whether ginseng or ginseng plus high protein diet have any protective effects on the liver of chronical alcoholist from developing malfunction enzymatic activities of both glutamic-pyruvic and glutamic-oxaloacetic transaminases were measured on serum of rats maintained with basal low protein diet, basal diet plus 1 percent ginseng and high protein (40%) plus 1 percent ginseng and administered intraperitoneally with a Constant amount of ethanol either periodically or chronically. It was found that, unlike human subject GOT content was exceedingly high and significant difference was found either among treatment or among sexes thus indicating that either ginseng intake or high protein diet plus ginseng has a protective effect on the liver function of ethanol treated rats. From these results, it was suggested that the dietary ginseng might, have a protective effect on the alcohol hepatic disturbance. As one of probable mechanisms for the characteristic pharmacological activity, it was considered that a secondary action of the saponin of the dietary ginseng would result in the anti-inflammatory through the stimulation of de nove synthesis of certain functional proteins in hepatic organs.

Keywords

References

  1. Transamination In review of physiological chemistry Harper, H.A.
  2. Proc. Soc. Exptl Biol. and Med. v.103 Separation of glutamic oxaloacetic transaminase by papes chromatography Fleisher, G.A.(et al.)
  3. Biocheim. Bophys. Acta. v.54 The intracellular localization of glutamic-oxaloacetic transaminase in heart Borst, P.;Peeters, E.M.
  4. J. Biol Chem. v.239 Immunochemical and Kinetic Properties of anionic and cationic glutamic oxaloacetic transaminase separated from human heart and human liver Nisslbaum, J.S.;Bodansky, O.
  5. J. Biol. Chem. v.239 Immunochemical distribution between glutamic oxaloactic transaminase the soluble and mitechondrial fraction of mammalian tissuse Morino, Y.S.(et al.)
  6. Enzymologia v.2 Principles of transamination Braumstein, A.E.;Kritzmann, M.G.
  7. J. Biol. Chem. v.136 Distribution of transaminase Cohen, P.P.
  8. J. Biol. Chem. v.194 Distribution of transaminte in rat organs Awapora, J.;Seals, B.
  9. J. Biol. Chem. v.161 The Specifi-city of transaminase Green De, E.;Leoloir, L.F.;Nocito, V.
  10. Biochim. Biophys. Acta v.65 The ebition of Go-I isozymes in rat organs Hook, D.H.;Vestlino, C.S.
  11. J. Biol. Chem. v.241 Kinetic and electrophoreties of the isozyme of aspartate aminotransferase from pigheart Nisselbaum, J.S.;Bodansky, O.
  12. J. Biol. Chem. v.239 Immunochemical and Kinetic Pioperties of aniomic and cationic glutamicoxaloacetic transaminase separated from human heart and liver Nisselbaum, J.S.;Bodansky, O.
  13. J. Clin, Investigation v.34 Determination of Serum Go-Tactivity in myocardial infarotion patient Karmen, A.;Worblewski, F.;Ladue, J.S.
  14. Minerva, Medicine v.46 Transaminase activity of human serum during the course of virus of virus heepatitis Deritis, F.;Coltorti, M.;Giustic, G.
  15. Enzymes in health and disease Greenberg, D.M.;Harper, H.A.
  16. Am. J. Clim. Pathol. v.28 Colorimetic method for the determination of serum transaminase activity Reitman, S.;Frankel, S.
  17. Sigma Technical Bllletin no.505 The colorimetric determinaton of GOT and GPT at 490-520nm in serum or other fluid
  18. J. Clin, Invest. v.34 A note on the Spectrophotometric activity assay of GOT in human blood serum Karmen, A.
  19. Clinical Medicine Jap. v.2 Pharmacologacol action of panax Ginseng inflvence of panaxginseng on the human metabolism Yoshida, T.I.;Yoshimitu, T.S.
  20. Keijo Igaku Jap. v.2 Action of panax ginseng on the experimental hyperglycemya Saido, I.H.
  21. The Seoul Journal of Medicine v.3 no.2 The action of panax ginseng on the glucose oxidtion of rat liver in vitro Kang, S.S.
  22. Toxic and drug-induced hepatitis Disease of the liver Klatskin, G.
  23. Textbook of Medicine Alcoholic hepatitis,Cecil-Loeb Paul, B.B.;Walsh MeDermott
  24. In Hans-Ulrich Bermeyer, Methods in enzymatic analsis Schmidet, E.;Schmidt, F.W.;Horn, H.D.;Gerlach, U.
  25. Korean Biochem. J. v.6 no.2 Stamulating effect of panax saponin on the $C^14$-leucine incr poration Han, H.B.;Kim, C.H.;Han, Y.N.
  26. J. of the pharm. Society of Korean v.16 Studies on the antiinflammatory glucosides of panax ginseng Han, B.H.;Han, Y.N.;Woo, L.K.