The Effects of Pretreatment with Carbon Tetrachloride on the Absorption and Excretion of Sulfisoxazole

사염화탄소(四鹽化炭素) 간장장해(肝臟障害) 동물(動物)에서의 Sulfisoxazole의 흡수(吸收)와 배설(排泄)에 관(關)한 연구(硏究)

This paper attempted to investigate the effect of pretreatment with carbon tetrachloride on absorption, excretion, protein binding, and biological half-life of sulfisoxazol from rats and rabbits. Absorption of sulfisoxazol was found to decrease in severe damage rats, compared with that of normal rats, but in mild rats, absorption of sulfisoxazol was similar to that of nomal rats. Absorption of sulfisoxazol was decreased significantly in severe damage rabbit pretreated with carbon tetrachloride but in mild damage rabbit, absorption of sulfisoxazol was not influenced significantly. Pretreatment with carbon tetrachloride gave the effect on clearance of sulfisoxazol in part but protein binding percent of sulfisoxazol was not influenced by concentration of carbon tetrachloride.