Effect of Low Atmospheric Pressure on Serum Glutamic Oxaloacetic Transaminase and Lactic Dehydrogenase Activities of Rats

低氣壓이 흰쥐의 血淸 Glutamic Oxaloacetic Transaminase 및 Lactic Dehydrogenase 活性에 미치는 影響

In order to determine the influence of low atmospheric pressure on serum glutamic oxaloacetic transaminase (SGOT) and serum lactic dehydrogenase (SLDH) activities of rats, blood samples were collected from laboratory-conditioned male rats of the Sprague-Dawley strain which were randomly grouped into control and the experimental subjected to a series of one hour-exposure a day to low atmospheric pressure of 500 and 380mmHg up to the the time of 15 day. Results obtained indicated that decompression caused marked alterations in SGOT and SLDH levels when compared to that of the control. The trend of increases or decreases in these enzyme levels were similar in both 500 and 380mmHg exposed rats although the changes were greater in the latter group. Thus, generally all the experimental rats showed temporary steady state to low atmospheric pressure. Changes in enzymatic contents depended on the intensity and extent of the environmental stress under study. The lower the atmospheric pressure the greater is the effect on these serum enzyme levels.

成熟한 Sprague-Dawley 系 雄性 흰쥐를 對照群(760 mmHg)과 低氣壓群인 500 mmHg 와 380 mmHg의 兩實驗群으로 나누어 15日間(1日當 1時間) 曝露시켜, 低氣壓이 血淸 glutamic oxaloacetic transaminase(GOT) 및 血淸 lactic dehydrogenase(LDH) 活性에 미치는 影響을 考察하였다. 血淸 GOT 및 LDH 含量은 兩群 共히 對照群에 比하여 顯著한 變化를 招來하였으며, 특히 GOT는 初期에 減少되고, 後期에 恒定持續性을 나타내어 對照群의 값에 近接하는 傾向이 나타났으며, 한편 LDH의 含量은 初期에 增加하고 後期에는 若干의 減少傾向이 나타났다. 一般的으로 이러한 變化는 흰쥐가 低氣壓의 曝露에 一時的인 恒定持續性을 나타내는 것을 보여주며 酵素의 含量의 變化는 低氣壓의 强度와 順化期間에 따라 다르며, 一般的으로 380 mmHg群은 500 mmHg群에 比하여 顯著한 變化相을 가져오는 것으로 思料된다.