A Study on the Development of Hypotensive Agent (I) -Hypotensive Action and Mechanism of Junci Herba in the Rabbit-

고혈압(高血壓) 치료제(治療劑)의 개발(開發)에 관(關)한 연구(硏究)(I) -등심초(燈心草)의 혈압강하(血壓降下) 작용(作用) 및 기전(機轉)-

The blood pressure response to Junci Herba water and methanol extracts in rabbit and $LD_{50}$ to Junci Herba water extract in mouse were investigated in order to develop a hypotensive agent from natural resources. $LD_{50}$ of Junci Herba water extract (WE) was 600 mg/kg in mouse, when WE was injected intraperitonealy. Junci Herba water and methanol extract, when injected into the vein of rabbit, produced a fall of blood pressure. Hypotensive effect of WE was suppressed by atropine and potentiated by phentolamine, while not affected by avil, propranolol, and phenoxybenzamine. Intravenous injection of chlorisondamine weakened the hypotensive effect of WE, and WE produced hypertensive effect in this rabbit. Intravenous injection of bretylium did not affect the hypotensive effect of WE, but WE produced hypertensive effect in this rabbit. In the rabbit treated with chlorisondamine, hypertensive effect of WE was suppressed by methysergide or bretylium, but not affected by atropine or phenoxybenzamine.