The Korean Journal of Pharmacology (대한약리학회지)
- Volume 10 Issue 1 Serial No. 15
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- Pages.41-45
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- 1974
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- 0377-9459(pISSN)
Effect of Ginseng Saponin on the Mobilization of Free Fatty Acid from Epididymal Fat Pad of Rat
인삼 Saponin이 백서부고환지방조직에서의 유리지방산동원에 미치는 효과
Abstract
The effect of ginseng saponin on the release of free fatty acid from adipose tissue was studied in vitro. 1. The mobilization of free fatty acid from intact epididymal fat pad of rat, incubated in Krebs-Ringer bicarbonate buffer (pH 7.4) contained bovine serum albumin (4 w/v%), was increased by addition of ginseng sponin (1 mg/ml). 2. The mobilization of free fatty acid from homogenate of the epididymal fat pad of rat, of which hormone-sensitive lipese system was activated by pre-incubation of intact fat pad in the presence of epinephrine, was markedly increased by addition of ginseng saponin
Krebs-Ringer bicarbonate 완충용액(pH 7.4, 4%(w/v) bovine serum albumin 함유)에 백서부고환지방조직을 incubation 하면서 FFA 유리에 대한 인삼 saponin의 작용을 관찰한 saponin 농도 1mg/ml에서 FFA의 유리가 현저히 증가되었으며 0.01mg/ml에서는 오히려 감소하였다. Epinephrine으로 전처치하여 hormone-sensitive lipase system을 활성화시킨 백서부고환지방조직 homogenate에서는
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