$\gamma$,$\gamma$,$\gamma$-Trichloroethylidene-m-Nitroacetophenone과 Hydrazine 들의 반응

Reactions of $\gamma$,$\gamma$,$\gamma$-Trichloroethylidene-m-Nitroacetophenone with Hydrazines

  • 이윤영 (서울대학교 문리과대학 화학과) ;
  • 송석주 (서울대학교 문리과대학 화학과)
  • Youn Young Lee (Department of Chemistry, College of Liberal Arts and Sciences, Seoul National University) ;
  • Suk Zu Song (Department of Chemistry, College of Liberal Arts and Sciences, Seoul National University)
  • 발행 : 1973.02.28

초록

$\gamma$,$\gamma$,$\gamma$-Trichloroethylidene-m-Nitroacetophenone과 phenylhydrazine및 치환된 phenylhydrazine들과의 반응으로 2,6-disubstituted-3-pyridazinone들을 합성하였으며 2,4-dinitrophenylhydrazine과의 반응에서는 hydrazone을 중간체로 분리하였다. hydrazinehydrate와의 반응에서는 3-(mnitrophenyl)-5-trichloromethyl-2-pyrazoline이 좋은 수득률로 얻어졌다. 또한$\gamma$,$\gamma$,$\gamma$-trichloroethylidene-m-nitroacetophenone과 치환된 phenylhydrazine과의 반응에서 phenyl기에 결합된 치환기의 효과를 검토하였다.

2,6-Disubstituted-3-pyridazinones were synthesized by the reactions of $\gamma$,$\gamma$,$\gamma$-trichloroethylidene-m-nitroacetophenone with phenylhydrazine and substituted phenylhydrazines, and hydrazone was isolated as an intermediate from the reaction with 2, 4-dinitrophenylhydrazine. From the reaction with hydrazine hydrate 3-(m-nitrophenyl)-5-trichloromethyl-2-pyrazoline was obtained in good yield. The effect of substituents on phenyl group in the reaction of $\gamma$,$\gamma$,$\gamma$-trichloroethylidene-m-nitroacetophenone with substituted phenylhydrazines was also discussed.

키워드

참고문헌

  1. This Journal v.14 Y.Y.Lee;W.Y.Lee;S.H.Chang
  2. This Journal v.16 Y.Y.Lee
  3. Ber. v.26 W. Konig;E. Wagstaff
  4. Ber. v.25 W. Konig
  5. M.S. Thesis, Graduate School, Seoul National University W. Y. Lee