On the chinoform metal chelate

Chinoform metal chelate에 관한 연구

Determinations of the compositioin ofl chinoform metal chelates by elemental analysis and molar ratio method showed that the ratios of the ligand to metals in chinoform Cu(II) chelate, chinofrm Ni (II) chelate, and chinoform CO(II) chelate were 2:1 respectively and that the ratio in chinoform Fe(III) chelate was 3:1. It was found that diffe rential thermal values vary with the center metalic ions and that the thermal stability was in anorder of Fe>Cu>Co>Ni. The indices of over-all stability constant of chinoform Cu(II) chelate, Ni(II) chelate, Co(II) chelate, and Fe(III) chelate were 15.57, 15.16, 15.40 and 20.76, respectively, and the over-all stability was in an order of Fe>Cu>Co>Ni. The tests of the natibacterial activity in vitro of the chinoform metal chelates against Staphylococcus aureus ATCC G538, Pseudomonas aeruginosa 2131, Serratia marcescens 3357, Klebsiella pneumoniae 8899, Enterococcus 3309, Streptococcus pyogenes 507, and Escherichia coli 125 showed that the Cu(II) chelate generally had greater activity than chinoform, that it had four-fold activity particularly against Streptococcus pyogenes 507 and Staphylococcus awreus ATCC 6538, that the Ni(II) and Co(II) chelates had almost same activity, and that the Fe chelate had strong activity against Escherichia coli 125.