Journal of Pharmaceutical Investigation

The Korean Society of Pharmaceutical Sciences and Technology (한국약제학회)
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Stop-flow Analysis of Urinary Excretion of Sulfadiazine in the Dog

Stop-flow방법(方法)으로 분석(分析)한 sulfadiazine의 요중(尿中) 배설(排泄) 기전(機轉)

  • Ko, Suk-Tai (Department of Pharmacology, College of Pharmacy, Cho Sun University) ;
  • Lee, Donn-Yil (Department of Pharmacology, College of Pharmacy, Cho Sun University) ;
  • Kim, Sung-Oh (Department of Pharmacology, College of Pharmacy, Cho Sun University) ;
  • Kim, Jae-Wan (Faculty of Pharmacy, Duk Sung Women's College)
  • 고석태 (조선대학교 약학대학 약물학교실) ;
  • 이돈일 (조선대학교 약학대학 약물학교실) ;
  • 김성오 (조선대학교 약학대학 약물학교실) ;
  • 김재완 (덕성여자대학 약학부)
  • Published : 1973.12.20
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Abstract

The mechanism of urinary excretion of sulfadiazine was investigated in the dogs by means of stop-flow technique Results of experiments were summarized as follows; 1. The ratios of U/P sulfadiazine to U/P creatinine $(U/P_{SD}:U/P_{cr})$ were always lower than 1 in all nephrons, showed a minimum in the proximal area. 2. $U/P_{SD}:U/P_{cr}$ were not affected by Probenecid or 2.4-DNP, whereas increased significantly by administration of sodium bicarbonate. 3. Probenecid did not alter the stop-flow patterns in alkalotic dog too. 4. $C_{SD}$ (clearance of sulfadiazine ) was appreciably influenced by change in urinary PH, or flow rate. All evidences lead to the conclusion that sulfadiazine reabsorption is passively transported by proximal tubules. No clue for active process, either secretory or reabsorptive, was obtained.

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