The Korean Journal of Physiology
- 제7권2호
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- Pages.1-8
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- 1973
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- 0300-4015(pISSN)
온도(溫度)가 가토(家兎) 폐포표면(肺胞表面) 활성물질(活性物質)의 활성도(活性度)에 미치는 영향(影響)
Effects of Temperature on the Activity of Pulmonary Surfactant of the Rabbit
- 권굉보 (경북대학교 의과대학 생리학교실)
- Kwon, Koing-Bo (Department of Physiology, Kyungpook National University School of Medicine)
- 발행 : 1973.12.01
초록
온도(溫度)에 대(對)한 폐포표면활성물질(肺胞表面活性物質)의 활성도(活性度)의 태도(態度)를 구명(究明)코져 가토(家兎)의 좌측(左側) 폐장(肺臟)을 적출(摘出)하여 생리적(生理的) 식염수(食鹽水)로 폐포세척액(肺胞洗滌液)을 작성(作成)하여 4 C에 1, 5, 10, 15, 30 및 40일간(日間) 방치(放置)한 군(群)과 20 C에 1, 2, 3, 4, 5 및 7일간(日間) 방치(放置)한 군(群) 및 정상가토(正常家兎)를 4 C에 4, 8, 12 및 24 시간(時間) 노출(露出)한 후(後) 좌측(左側) 폐장(肺臟)을 적출(摘出)하고 폐포세척액(肺胞洗滌液)을 작성(作成)한 군(群)에서 그 표면장력(表面張力)을 측정(測定)하여 정상가토(正常家兎)의 그것과 비교(比較) 결과(結果)는 다음과 같다. 1) 정상가토(正常家兎)의 폐포세척액(肺胞洗滌液)의 최대(最大) 및 최소표면장력(最小表面張力)및 stability index는 각각(各各)
Though it has been reported by Clements et al. and Avery et al. that the activity of the pulmonary surfactant can be altered by the temperature changes, a conclusive evidence of the effects of temperature on the surfactant system of the lung is yet to come. In the present study, an attempt was made to observe possible effects of a few different degrees of temperature on the activity of the pulmonary surfactant of the rabbit in vivo and in vitro. The rabbit was sacrificed by blood shedding and both lungs were completely removed. The lung washings, obtained by gently lavaging the left lung with saline, was placed at 1) 4C for 1, 5, 10, 15, 30 and 40 days, and 2) 20C for 1, 2, 3, 4, 5 and 7 days for in vitro experiment. For in vivo experiment, the rabbit was placed at 4C for 4, 8, 12 and 24 hours, and the lung lavage was prepared as described above in the in vitro experiment. Tension-area (T-A) diagram of the lung lavage was recorded automatically by a modified. Langmuir-Wilhelmy balance with a synchronized recording system. The surface tensions thus obtained were compared with those of the normal rabbit, and the results are summarized as follows: 1. The maximal surface tension, minimal surface tension and stability index of the normal rabbit lung lavage were
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