대한약리학회지 (The Korean Journal of Pharmacology)
- 제8권2호
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- Pages.41-47
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- 1972
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- 0377-9459(pISSN)
Fluoride가 적출장기(摘出臟器)의 Catecholamine 유리(遊離) 및 Monoamine Oxidase 활성도(活性度)에 미치는 영향(影響)
The Influence of Sodium Fluoride on the Release of Catecholamine from Perfused Organs and Monoamine Oxidase Activity
- Cheon, Yun-Sook (Department of Pharmacology, College of Medicine, Korea University) ;
- Kim, Sung-Sook (Department of Pharmacology, College of Medicine, Korea University) ;
- Lee, Kyung-Hee (Department of Pharmacology, College of Medicine, Korea University) ;
- Shin, Kyung-Chul (Department of Pharmacology, College of Medicine, Korea University)
- 발행 : 1972.12.30
초록
Fluorides were supposed to exert a stimulatory action on the catecholamine release. In this study, the authors attempted to investigate the action of sodium fluoride on the catecholamine release from the isolated perfused cow adrenal gland and rat heart. And also the inhibitory effect of sodium fluoride on the monoamine oxidase activity in rat heart and liver mitochondria was investigated. The monoamine oxidase activity was measured by the conversion of benzylamine to benzaldehyde. The results obtained were follows; 1. Sodium fluoride stimulated the release of catecholamine from the isolated perfused cow adrenal gland and rat heart. 2. Sodium fluoride inhibited the rat heart and liver mitochondrial monoamine oxidase activity.
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