대한약리학회지 (The Korean Journal of Pharmacology)
- 제8권1호
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- Pages.77-87
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- 1972
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- 0377-9459(pISSN)
대황의 알콜추출물이 토끼 적출장관에 미치는 영향
Effect of Alcohol Extract of Rheum undulatum Linne on Isolated Rabbit Intestine Strip
- Kim, Won-Ja (Department of Pharmacology, Catholic Medical College) ;
- Paek, Un-Sang (Department of Pharmacology, Catholic Medical College) ;
- Ha, Byoung-Kuk (Department of Pharmacology, Catholic Medical College) ;
- Kim, Ki-Jin (Department of Pharmacology, Catholic Medical College)
- 발행 : 1972.06.30
초록
Korean rheum (Rheum undulatum Linne) as one of the botanical crude drugs which belong to polygonaceae family has been extensively applied in Chinese medicine during the last decades. It has been particularly used in cathartic and gastric tonic among the folk remedies. There are, however, a few reports with regard to the pharmacological effects on the motility of intestines of several animals. The authors hereby paid attention to this point of view and made experiment to examine the relationship between the alcohol extract of Korean rhei rhizoma and the motility of the isolated rabbit intestine, making the use of several drugs related to the motility of intestine such as acetylcholine, pilocarpine, atropine, papaverine, serotonin, and barium chloride. The movement of the isolated rabbit intestine in Tyrode's solution was recorded with the electric kymograph according to the Magnus method. The results of the experiment are as follows. 1. The motility of the isolated rabbit intestine represents the tendency of gradual dilatation in proportion to the concentration of R-A
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