Studies on the Synthesis and Antitumor Actiities of Potential Antineoplastic Agents. IV. Synthesis and Antitumor Activities of N-Substituted-p-Arsanilic Acid

제암성물질의 합성및 항종양시험에 관한 연구 IV N-치환, p-Arsanilic Acid 유도체의 합성 및 항종양시험

Seven organic arsine compounds are synthesized as potential anti-tumor agents are subjected to the screening test of activity against SN-36 Leukemia, Sarcoma 180 and Ehrlich ascites carcinoma. Three compounds, namely N-(5-Nitrofroyl)-p-arsanilic acid, N-(2, 4-Dihydroxybenzoethyl)-p-arsanilic acid and N-$\alpha$(p-arsanilido) acetyl thiourea of the all synthesized compounds showed comparatively potential activities against experimental ascitic tumors both through cytological findings and survival duration.