Chromosome Studies on the Cultured Uterine Carcinoma Cells

배양한 子宮癌세포의 염색체에 관한 연구

The conclusions established in the present study on the chromosomes in vitro of the uterine carcinomas of Korean women are as follows: 1. The pattern of the distribution of chromosome number in uterine carcinoma cells was quite different from that of normal cells, and modal number of the chromosome was 45 and 46. 2. The frequency of diplochromosomes was 0.053 per cell (5.3%) and that of chromosome aberration was 0.16 per cell (16%), which are significantly higher than each of normal cells. In chromosome aberration types, chromatid and isochromatid deletions (chromatid type) and dicentric (chromosome type) were observed. 3. Idiogram analysis showed a tendency that the number of chromosomes belonging to group F increased while that of chromosomes in groups B and E decreased in total. The number of chromosomes in groups C and G in the hypodiploidy cells decreased, but it increased in the hyperdiploidy cells.

한국부인의 子宮癌細胞에 관한 본 연구결과는 다음과 같다. 1. 種族細胞의 染色體數는 45와 46의 2종류임을 확인했다. 2. 染色體 형태에 있어서 diplochromosome 의 출현율이 높아 5.3%을 나타낸다. 染色體 異常率은 細胞당 0.16이고, 異常型으로는 染色分體缺矢, 同位染色分體缺矢의 染色分體異常型과 2動原體인 染色體異常型이 보였다. 3. 核型을 분석한 결과 전체로는 그르프 F의 染色體數의 증가와 그르프 B 및 E의 감소경향을 보여주었다. 이것이 低2倍性인 細胞에서는 그르프C 및 G에서 감소하고, 반대로 高2倍性에서는 그르프C 및 G에서 증가하는 경향이 있었다.