Bleomycin Used for Esophageal and Lung Carcinoma: Clinical Two Cases Report

악성 종양에 대한 Bleomycin 사용 경험례: 식도 및 폐암의 2예

  • Lee, Yang-Sam (Department of Thoracic Surgery, Catholic Medical College) ;
  • Kwack, Moon-Sub (Department of Thoracic Surgery, Catholic Medical College) ;
  • Kim, Se-Wha (Department of Thoracic Surgery, Catholic Medical College)
  • 이양삼 (가톨릭의대 부속성모법원 흉부외과 교실) ;
  • 곽문섭 (가톨릭의대 부속성모법원 흉부외과 교실) ;
  • 김세화 (가톨릭의대 부속성모법원 흉부외과 교실)
  • Published : 1970.12.01

Abstract

Bleomycin is known as a antibiotic agent for malignant tumors especially sguamous cell carcinoma. We have treated 2 cases of malignant tumors, each one esophageal and lung carcinoma with bleomycin, 630 mg and 510 mg respectively. In case of esophageal carcinoma. the subjective symptoms such as dysphagea and swallowing disturbance are temporally relieved, but the irregular filling defect is not significantly changed in esophagogram. In case of lung carcinoma, the atelectasis of right upper lobe on chest X-ray was slightly regressed in its size without effective improvement of subjective symptoms. However, following additional radioactive $^60{Co}$ irradiation therapy (5200r), marked regression of tumor density and aeration of right upper lobe was observed. But 2 weeks later of ceasatioil of irradiatio:J, atelectasis of right upper lobe was again developed. Fever, anorexia, headache and eruption were developed during the treatmeat with bleomycin in both cases but the sign or symptoms of hone marrow depression, renal or liver damage were not noted.

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