대한약리학회지 (The Korean Journal of Pharmacology)
- 제4권1호
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- Pages.33-36
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- 1968
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- 0377-9459(pISSN)
창출(蒼朮) Alkaloid 가 Schedule Controlled Behavior 에 미치는 영향(影響)
The Effect of Atractylis Alkaloid on Schedule-Controlled Behavior
- Hong, Sa-Ack (Department of Pharmacology, College of Medicine, Seoul National University) ;
- Moon, Dong-Yeon (Department of Pharmacology, College of Medicine, Seoul National University)
- 발행 : 1968.12.01
초록
The effect on schedule controlled behavior and toxicity of Atractylis alkaloid was investigated in the pigeons which were trained on a multiple fixed-ratio fixed-interval schedule of food presentation. Atractylis alkaloid decreased the rate of responding during both the fixed-interval and fixed ratio component of the schedule at 10 mg/kg. Further depression occurred at 30 mg/kg. This 'flat dose-response curve for depression of conditioned behavior was typical of tranquilizers. Conclusively it was suspected that Atractylis alkaloid had major tranquilizing activity.
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