The Bacteriostatic Action of Trichlorophenoxy Alkylene Ammonium Derivatives and their Synthesis

Trichlorophenoxy alkylene ammonium 유도체(誘導體)의 합성(合成) 및 살균작용(殺菌作用)에 관(關)한 연구(硏究)

  • Kang, Shin-Wang (Department of Pharmacology Kyungpook National University, School of Medicine) ;
  • Cha, Choong-Suk (Department of Pharmacology Kyungpook National University, School of Medicine) ;
  • Yun, Hea-Chung (Department of Pharmacology Kyungpook National University, School of Medicine) ;
  • Kim, Hwa-Woong (Department of Pharmacology Kyungpook National University, School of Medicine) ;
  • Kim, Chung-Yung (Department of Pharmacology Kyungpook National University, School of Medicine) ;
  • Lee, Dae-Soo (Department of Organic Chemistry Kyungpook National University, School of Leveral Art & Science)
  • 강신완 (경북대학교 의과대학 약리학교실) ;
  • 차충석 (경북대학교 의과대학 약리학교실) ;
  • 윤희정 (경북대학교 의괴대학 약리학교실) ;
  • 김화웅 (경북대학교 의과대학 약리학교실) ;
  • 김중영 (경북대학교 의과대학 약리학교실) ;
  • 이대수 (경북대학교 문리과대학 유기화학연구실)
  • Published : 1966.12.30

Abstract

The bacteriostatic action of trichlorophenoxy alkylene ammonium derivatives, 2(2,4,5-trichlorophenoxy) ethylene N-triethyl ammonium bromide; (2,4,5-TETB), 2(2,4,6-trichlorophenoxy) ethylene N-triethyl ammonium bromide; (2,4,6-TETB), 2,4,5-triphenoxy ethylene pyridinium bromide; (2,4,5-TEPB), and 2,4,6-trichlorophenoxy ethylene pyridinium bromide:(2,4,6-TEPB) were observed by Jackson and Finland's and Finland's and Pak's on Staphylococcus aureus, E. coli, Salmonella typhi, Shigella flexneri, and Bacillus subtilis, comparing with those of phenol and trichlorophenol. The following results were obtained. 1) Phenol is bacteriostatic in a concentration of $10^{-3}$ for all above species. 2) Trichlorophenol is bacteriostatic in concentration of $10^{-4}$ to $5{\times}10^{-5}$ for all above species(Table 7), 3) 2,4,5-TETB and 2,4,6-TETB are bacteriostatic in a concentration of $10^{-4}$ and $5{\times}10^{-5}$ for Staphylococcus aureus, Salmonella typhi, and Shigella flexneri, but do not for E. coli and Bacillus subtilis(Table 8 and 9). 4) 2,4,5-TEPB and 2,4,6-TEPB are bacteriostatic in a concentrationof $10^{-4}$ and $5{\times}10^{-5}$ only for Staphylococcus aureus among four species(Table 10 and 11).

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