Studies on the Organic Base Complexes and their Application to Analytical Chemistry. I. A Study on the Formation of Chlorpromazine Bromothymol Blue Complex and its Application to Analytical Chemistry.

4 유기염기착화합물의 분석화학적연구 I. Chlorpromazine Bromthymol Blue Complex 의 분석화학적연구

It has been known that the organic base complexes formed with the anionic acid base indicators are highly soluble in non-polar solvents but relatively insoluble in water. In the work reported here the formation of the complex between chloropromazine and bromothymol blue was studied and applied it to the determination of the base. The values to determine the binding ratio of the base with the indicator at pH 3.5 obtained from the application of Job's method of continuous variation and mol ratio method were both 1:1. From the application of this reaction to the determination of the base with carbon tetrachloride as the solvent for the extraction, fairy good results have been obtained.