Journal of the Korean Chemical Society (대한화학회지)

Korean Chemical Society (대한화학회)
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A Study on the Knoevenagel Reaction of Fluorinated Carbonyl Compounds

含弗素有機 Carbonyl化合物의 Knoevenagel反應에 關한 硏究

  • 김유선 (原子力硏究所 化學硏究室)
  • Published : 19630300
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Abstract

The Knoevenagel reaction of fluorinated carbonyl compounds, 1,1,1-trifluoro-propanone-2-heptafluoro-butyraldehyde, 1,3-dichloro-1,1,3,3-tetrafluoro-acetone, tetradecafluoro-heptanone-4 and 2,2,2-trifluoro-acetophenone yielded fluorinated ${\beta},{\beta}$-dialkyl-${\beta}$-hydroxy acids. Dehydration of the acids do not give the olefinic acid in the case of the perfluorinated system and gave a lactone. From the consideration of electronic and steric effects a mechanismic path of the reaction via a carbanion intermediate was proposed for the reaction. Preparation of related derivatives are also described.

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References

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