약학회지 (YAKHAK HOEJI)
- 제6권1호
- /
- Pages.25-27
- /
- 1962
- /
- 0377-9556(pISSN)
- /
- 2383-9457(eISSN)
2-acrtyl-11-keto-.DELTA.12;13-oleanolic ketol acetate급 기타 유도체의 합성
Synthesis of 2-acetyl 11-keto-.DELTA.12;13 oleanolic ketol acetate and other derivatives
초록
The derivative of glycyrrhetinic acid which have similar effects of desoxycorticosterone acetate was prepared glycyrrhetinyl chloride by the chlorination with thionyl chloride at low temperature. 2-Acetyl-11-keto-.DELTA. : 13 oleanolic ketol acetate (30) was synthesized by diazotating glycyrrhetinyl chloride with diazomethan and the acetylation with anhydro acetic acid. 2-Acetyl-.DELTA.12 : 13 oleanolic ketol acetate (28) was synthesized by chlorinating oleanolic acid with thionyl chloride, and by diazotatating oleanolyl chloride with diazomethan and the acetylation with anhydroacetic acid.
키워드