SMOTE-ADNet: 향상된 CNN 과SMOTE 를 활용한 알츠하이머병 및 초기 단계 정확한 분류

SMOTE-ADNet Leveraging Enhanced CNN and SMOTE for Accurate Classification of Alzheimer's Disease and Early Stages

  • 손소영 (성균관대학교 전자전기컴퓨터공학과) ;
  • 추현승 (성균관대학교 전자전기컴퓨터공학과)
  • Sun Xiaoying (Dept. of Electrical and Computer Engineering, Sungkyunkwan University) ;
  • Hyunseung Choo (Dept. of Electrical and Computer Engineering, Sungkyunkwan University)
  • 발행 : 2024.10.31

초록

Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by gradual cognitive decline and memory loss, with subtle changes in brain structure that make accurate classification particularly challenging. This study presents SMOTE-ADNet, an innovative Convolutional Neural Network (CNN) model designed to enhance classification performance for Alzheimer's disease by integrating advanced CNN techniques with the Synthetic Minority Over-sampling Technique (SMOTE). The SMOTE-ADNet architecture includes multiple convolutional layers, dropout regularization, and a final dense layer optimized for multi-class classification, aimed at differentiating between five stages of Alzheimer's disease: Alzheimer's disease (AD), Cognitive Normal (CN), Early Mild Cognitive Impairment (EMCI), Late Mild Cognitive Impairment (LMCI), and Mild Cognitive Impairment (MCI). Given the challenge of distinguishing between subtle variations in brain structure during these stages, SMOTE-ADNet effectively balances the dataset using SMOTE and leverages advanced CNN layers to achieve a remarkable accuracy of 98%. This result demonstrates the model's capability to manage the inherent difficulty of classifying subtle structural differences and its potential for improving diagnostic precision and aiding early intervention in Alzheimer's disease.

키워드

과제정보

This work was supported in part by the BK21 FOUR Project (50%) and the Korea government (MSIT), IITP, Korea, under the ICT Creative Consilience program (RS-2020-II201821, 25%), Development of Brain Disease (Stroke) (RS-2024-00459512, 25%).

참고문헌

  1. Doaa Ahmed Arafa etc. "A deep learning framework for early diagnosis of Alzheimer's disease on MRI images" Multimedia Tools and Applications, 83(2), 3767--3799
  2. Dongdong Chen etc. "Learnable Subdivision Graph Neural Network for Functional Brain Network Analysis and Interpretable Cognitive Disorder Diagnosis" MICCAI Canada 2023, pp 56-66
  3. Blagus, Rok, Lusa, Lara "SMOTE for high-dimensional class-imbalanced data" BMC bioinformatics, volume 14, pp 1-16