Acknowledgement
This work was supported by R&D Program for Forest Science Technology (Project No. 2021377C10-2123-BD02) provided by Korea Forest Service (Korea Forestry Promotion Institute).
Proceedings of the Plant Resources Society of Korea Conference (한국자원식물학회:학술대회논문집)
- 2023.04a
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- Pages.43-43
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- 2023
Inhibitory Activity of Wild-Simulated Ginseng against Non-Alcoholic Fatty Liver Disease in HepG-2 Cells
- So Jung Park (Department of Forest Science, Andong National University) ;
- Yurry Um (Forest Medicinal Resources Research Center, National Institute of Forest Science) ;
- Min Yeong Choi (Department of Forest Science, Andong National University) ;
- Jin Boo Jeong (Department of Forest Science, Andong National University)
- Published : 2023.04.27
Abstract
In this study, we investigated in vitro inhibitory activity of wild-simulated ginseng (WSG) against non-alcoholic fatty liver disease using HepG-2 cells. T0901317 treatment increased the lipid accumulation in HepG-2 cells, but WSG treatment inhibited T0901317-mediated lipid accumulation. In addition, WSG downregulated T0901317-mediated expression of SREBP-1c, ACC, FAS and SCD-1 protein. In addition, WSG increased the phosphorylation level of LKB1 and AMPK. Compound C treatment blocked WSG-mediated downregulation of SREBP-1c protein. In conclusion, WSG is considered to inhibit the accumulation of lipids and triglycerides in HepG-2 cells by inducing the activation of LKB1 and AMPK successively, thereby reducing the expression of FAS, ACC, and SCD-1 through suppression of SREBP-1c expression.
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