Acknowledgement
This work was carried out with the support of "Cooperative Research Program for Agriculture Science and Technology Development (Project No. PJ017090052022)" Rural Development Administration, Republic of Korea.
Proceedings of the Plant Resources Society of Korea Conference (한국자원식물학회:학술대회논문집)
- 2023.04a
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- Pages.42-42
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- 2023
A Study on Extraction Conditions of Paeonia lactiflora for High Immunostimulatory Activity
- Jeong Won Choi (Department of Forest Science, Andong National University) ;
- Hyeok Jin Choi (Department of Forest Science, Andong National University) ;
- Gwang Hyeon Ryu (Department of Forest Science, Andong National University) ;
- Seung Woo Im (Department of Forest Science, Andong National University) ;
- Jae Won Lee (Department of Forest Science, Andong National University) ;
- Jin Boo Jeong (Department of Forest Science, Andong National University)
- Published : 2023.04.27
Abstract
Paeonia lactiflora roots (PLR) are a traditional medicinal plant used to treat inflammatory diseases. Recently, PLR has been reported to increase the secretion of immune regulatory factors and enhance phagocytic activity in macrophages. Therefore, in this study, we compared the macrophage activation induced by PLR under different extraction conditions. PLR extracts at temperatures ranging from 4℃ to 60℃ increased the secretion of immune regulatory factors, but the secretion slightly decreased at 80℃. Under time-based extraction conditions at 60℃, immune regulatory factor secretion by PLR extracts was similar from 1 to 24 hours. Therefore, considering the overall results of this study, extracting PLR at 60℃ for 1 hour is considered the optimal condition for macrophage activation.
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