식물 유래 물질 해독화를 통한 고부가가치 소재 생산

Improving Production of Value-added Materials by a Detoxification of Plant Derivatives

  • 황성민 (국립호남권생물자원관 실용화연구부) ;
  • 박정업 (국립호남권생물자원관 실용화연구부) ;
  • 윤보현 (국립호남권생물자원관 실용화연구부) ;
  • 박지원 (국립호남권생물자원관 실용화연구부) ;
  • 이원우 (국립호남권생물자원관 실용화연구부)
  • Sungmin Hwang (Honam National Institute of Biological Resources, Division of Practical Research) ;
  • Jung Up Park (Honam National Institute of Biological Resources, Division of Practical Research) ;
  • Bohyun Yun (Honam National Institute of Biological Resources, Division of Practical Research) ;
  • Ji-Won Park (Honam National Institute of Biological Resources, Division of Practical Research) ;
  • WonWoo Lee (Honam National Institute of Biological Resources, Division of Practical Research)
  • 발행 : 2023.04.27

초록

Plant biomass, or lignocellulose, is one of the most abundant natural resources on earth. Lignocellulosic biomass, such as agricultural and forestry residue, serves as a renewable feedstock for microbial cell factories due to its low price and abundant availability. However, the recalcitrance of lignocellulosic biomass requires a pretreatment process prior to microbial fermentation, from which fermentable sugars including xylose and glucose are generated along with various inhibitory compounds. The presence of furan derivatives, such as 5-hydroxymethyl-2-furaldehyde and 2-furaldehyde (furfural), hampers the microbial conversion of lignocellulosic biomass into value-added commodities. In this study, furfural tolerance was improved by investigating the detoxification mechanism in non-model yeast. The genes encoding aldehyde dehydrogenases were overexpressed to enhance furfural tolerance and resulted in improving cell growth and lipid production that can be converted into biofuel. Taken together, this approach contributes to the understanding of the reducing toxicity mechanism of furfural by the aldehyde dehydrogenases and provides a promising strategy that the use of microorganism as an industrial workhorse to treat efficiently lignocellulosic biomass as sustainable plant derivatives.

키워드

과제정보

본 연구 발표는 국립호남권생물자원관 연구과제(HNIBR202302113)의 지원에 의해 이루어진 결과로 이에 감사드립니다.