과제정보
This work was carried out with the support of "Cooperative Research Program for Agriculture Science and Technology Development (Project No. PJ01424602)" Rural Development Administration, Republic of Korea.
한국자원식물학회:학술대회논문집 (Proceedings of the Plant Resources Society of Korea Conference)
- 한국자원식물학회 2021년도 춘계학술대회
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- Pages.65-66
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- 2021
Sprague-Dawley rats에서 감초 신품종 추출물의 단회투여 독성 평가
Assessment of the Single Oral dose Toxicity of Glycyrrhiza New Variety Extract in Sprague-Dawley Rats
- 김동구 (전북대학교 환경생명자원대학 한약자원학과) ;
- 이정훈 (농촌진흥청 국립원예특작과학원 약용작물과) ;
- 김원남 (Cnh 암의학연구소) ;
- 안효진 (상지대학교 한의과대학 약리학교실) ;
- 이종현 (동덕여자대학교 약학대학 약학과) ;
- 장재기 (농촌진흥청 국립식량과학원 작물재배생리과) ;
- 강사행 (전북대학교 환경생명자원대학 한약자원학과) ;
- 송영재 (전북대학교 환경생명자원대학 한약자원학과) ;
- 전용덕 (우석대학교 약학대학 한약학과) ;
- 진종식 (전북대학교 환경생명자원대학 한약자원학과)
- Dong-Gu Kim (Department of Oriental Medicine Resources, Jeonbuk National University) ;
- Jeonghoon Lee (Herbal Crop Research Division, NIHHS, RDA) ;
- Wonnam Kim (Cnh Center for Cancer Research) ;
- yo-Jin An (Department of Pharmacology, College of Korean Medicine, Sangji University) ;
- Jong-Hyun Lee (Department of Pharmacy, College of Pharmacy, Dongduk Women's University) ;
- Jaeki Chang (Crop Production & Physiology Division, NICS, RDA) ;
- Sa-Haeng Kang (Department of Oriental Medicine Resources, Jeonbuk National University) ;
- Young-Jae Song (Department of Oriental Medicine Resources, Jeonbuk National University) ;
- Yong-Deok Jeon (Department of Korean Pharmacy, College of Pharmacy, Woosuk University) ;
- Jong-Sik Jin (Department of Oriental Medicine Resources, Jeonbuk National University)
- 발행 : 2021.04.29
초록
Glycyrrhiza species (Licorice) are one of the most commonly used medicinal plants in Asian countries such as China, India and Korea. It has been traditionally used to treat many disease including cough, cold, asthma, fatigue, gastritis and respiratory tract infections. Glycyrrhiza new variety, Wongam (WG), have been developed by Korea Rural Development Administration and revealed several pharmacological effects. However, limited data are available on the potential adverse effects of the WG. Here, we evaluated the general toxicity of the WG extract through single oral dose toxicity study in Sprague-Dawley rats. After single oral dose administration, there was no mortality up to 5000 mg/kg during experiment period. In addition, there was no clinical signs including body weight change, gross findings and necropsy findings up to 5000 mg/kg during experiment period. To conclude, the no-observed-adverse-effect level (NOAEL) of WG was higher than 5000 mg/kg and no target organs were identified in male and female Sprague-Dawley rats.