Proceedings of the Plant Resources Society of Korea Conference (한국자원식물학회:학술대회논문집)
- 2021.04a
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- Pages.55-55
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- 2021
Hibiscus hamabo Exerts Anti-inflammatory Effects in Lipopolysaccharide-induced RAW 264.7 Cells
- Seo-Hyun Yun (Department of Medical Beautycare, Jungwon University) ;
- Ji-Eun Yang (Department of Medical Beautycare, Jungwon University) ;
- Jong-Yun Im (Medicinal Plant Science, Jungwon University) ;
- So-Yeon Han (Pharmaceutical Science, Jungwon University) ;
- Hye-Jeong Park (Medicinal Plant Science, Jungwon University) ;
- Jeong-Yong Park (Medicinal Plant Resources, Andong National University) ;
- Mi-Ji Noh (Department of Medical Beautycare, Jungwon University) ;
- Soo-Yeon Kim (Pharmaceutical Science, Jungwon University) ;
- Tae-Won Jang (Pharmaceutical Science, Jungwon University) ;
- Jae-Ho Park (Department of Medical Beautycare, Jungwon University) ;
- Ji-Sun Mun (Pharmaceutical Science, Jungwon University)
- Published : 2021.04.29
Abstract
Hibiscus hamabo is a deciduous shrub that grows around salt marshes and is considered a semi-mangrove plant found in Asia. There are no studies on the biological activity of H. hamabo except for studies on the anthocyanin content. We investigated the anti-inflammatory effects of H. hamabo extract (HHE) on lipopolysaccharide (LPS)-induced RAW 264.7 cells. As nuclear factor-kappa B (NF-kB) induced by LPS moves into the nucleus, inducible NO synthase (iNOS), cyclooxygenase-2 (COX-2), and inflammatory cytokines are promoted and the inflammatory reaction begins. The nitric oxide (NO) production decreased by the treatment of HHE. Moreover, mRNA levels of inflammation-related cytokines, such as tumor necrosis factor-α (TNF-α), interleukin (IL)-6, and IL-1β, were significantly suppressed by HHE. Similarly, the expressions of iNOS and COX-2 were also decreased. The phosphorylation of p65, a subunit of NF-κB, was suppressed by HHE. As a result, HHE can be used as an effective natural material for the anti-inflammatory agent.