과제정보
본 연구는 전주농생명소재연구원 연구소기업설립사업의 지원에 의해 이루어진 결과로 이에 감사드립니다.
한국자원식물학회:학술대회논문집 (Proceedings of the Plant Resources Society of Korea Conference)
- 한국자원식물학회 2020년도 추계국제학술대회
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- Pages.73-73
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- 2020
In vitro Anti-inflammation Effect of Adventitious Shoots of Toona sinesis in Propionibacterium acnes-induced Skin Dermatitis
- Hyeon-Ji Lim (Jeonju AgroBio-Materials Institute) ;
- In-Sun Park (Jeonju AgroBio-Materials Institute) ;
- Seung-Il Jeong (Jeonju AgroBio-Materials Institute) ;
- Kang-Yeol Yu (Jeonju AgroBio-Materials Institute) ;
- Chan-Hun Jung (Jeonju AgroBio-Materials Institute)
- 발행 : 2020.12.11
초록
Toona sinensis (TS) leaf is known to antinociceptive, antioxidative stress and skin moisturizing effects. Acnes vulgaris is a chronic skin disease with various symptoms including itchiness, pain and interruption of normal skin function. Propionibacterium acnes (P. acnes) is a major factor in the occurrence of inflammatory acnes. This study evaluated the antioxidant and anti-inflammation effects by TS extract from adventitious shoots. TS extract showed anti-inflammatory activities by suppression of pro-inflammation mediators (iNOS and COX-2) in LPS-stimulated RAW264.7 cells. TS extract also has anti-inflammatory activities by inhibiting the secretion of pro-inflammatory cytokines on P. acnes-stimulated HaCaT cells. These effects were regulated by MAPK signaling pathway. Therefore, we suggest that TS extract from adventitious shoots might have applications as a medicine for treating P. acnes-induced skin diseases.