Proceedings of the Plant Resources Society of Korea Conference (한국자원식물학회:학술대회논문집)
- 2019.10a
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- Pages.104-104
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- 2019
Anti-inflammatory Activity of Licorice Varieties on Inflammatory Responses in LPS-induced RAW 264.7 Macrophages
- Kang, Sa-Haeng (Department of Oriental Medicine Resources, Chonbuk National University) ;
- Song, Young-Jae (Department of Oriental Medicine Resources, Chonbuk National University) ;
- Jeon, Yong-Deok (Department of Oriental Medicine Resources, Chonbuk National University) ;
- Soh, Ju-Ryun (Department of Oriental Medicine Resources, Chonbuk National University) ;
- Lee, Jeong-Hoon (Department of Herb Crop Research, NIHHS, RDA) ;
- Park, Chun-Geon (Department of Herb Crop Research, NIHHS, RDA) ;
- Jang, Jae-Ki (Department of Herb Crop Research, NIHHS, RDA) ;
- Jin, Jong-Sik (Department of Oriental Medicine Resources, Chonbuk National University)
- Published : 2019.10.18
Abstract
Licorice species (Glycyrhiza species) are perennial plants belonging to the Leguminosae family. Licorice is world-widely distributed in Asia, Europe, and the Americas. The licorice species, such as Glycyrhiza uralensis (G. uralensis) and G. glabra, have been widely used in traditional oriental medicine. G. uralensis is found in Central Asia to the northeastern part of China and G. glabra is distributed from southern Europe to the northwestern part of China. These licorice species are characterized by having various pharmacological activities, including anti-oxidant, anti-inflammatory, immune improvement, and anti-tumor effects. In this study, we investigated the comparative anti-inflammatory effects of four licorice varieties (G. glabra L., G. uralensis FISCH., Shinwongam, and Wongam) on LPS-induced inflammatory responses in RAW 264.7 macrophage cell line. We evaluated the cytotoxicity of licorices at various concentrations. In addition, the nitric oxide (NO) production was elucidated by the treatment of licorice.