Proceedings of the Plant Resources Society of Korea Conference (한국자원식물학회:학술대회논문집)
- 2019.10a
- /
- Pages.92-92
- /
- 2019
Anthocyanins from Hibiscus syriacus L. Attenuate LPS-Induced Inflammation by Inhibiting the TLR4-Mediated NF-κB Signaling Pathway
- Karunarathne, Wisurumuni Arachchilage Hasitha Maduranga (Department of Marine Life Science, Jeju National University) ;
- Molagoda, Ilandarage Menu Neelaka (Department of Marine Life Science, Jeju National University) ;
- Lee, Kyoung Tae (Department of Biochemistry, College of Oriental Medicine, Dong-Eui University) ;
- Choi, Yung Hyun (Forest Biomaterials Research Center, National Institute of Forest Science) ;
- Kang, Chang-Hee (Nakdong National Institute of Biological Resources) ;
- Jeong, Jin-Woo (Nakdong National Institute of Biological Resources) ;
- Kim, Gi-Young (Department of Marine Life Science, Jeju National University)
- Published : 2019.10.18
Abstract
Excessive or chronic inflammation contributes to the pathogenesis of many inflammatory diseases such as sepsis, rheumatoid arthritis, and ulcerative colitis. Hibiscus syriacus L. has been used as a medicinal plant in many Asian countries, even though its anti-inflammatory activity has been unclear. Therefore, we investigated the anti-inflammatory effect of anthocyanin fractions from the H. syriacus L. varieties Pulsae (PS) on the lipopolysaccharide (LPS)-induced expression of proinflammatory mediators and cytokines in RAW264.7 macrophages. PS suppressed LPS-induced nitric oxide (NO) and prostaglandin
Keywords