Proceedings of the Plant Resources Society of Korea Conference (한국자원식물학회:학술대회논문집)
- 2019.10a
- /
- Pages.8-8
- /
- 2019
Bacterial Stringent Signal Directs Virulence and Survival in Vibrio cholerae.
- Oh, Young Taek (Department of Animal and Plant Research, Nakdonggang National Institute of Biological Resources) ;
- Kim, Hwa Young (Department of Microbiology and Immunology, Yonsei University College of Medicine) ;
- Yoon, Sang Sun (Department of Microbiology and Immunology, Yonsei University College of Medicine)
- Published : 2019.10.18
Abstract
The stringent response (SR) is characterized as a bacterial defense mechanism in response to various growth-inhibiting stresses. It is activated by accumulation of a small nucleotide regulator, (p)ppGpp, and induces global changes in bacterial transcription and translation. Recent work from our group has shown that (p)ppGpp plays a critical role in virulence and survival in Vibrio cholerae. The genes, relA and relV, are involved in the production of (p)ppGpp, while the spoT gene encodes an enzyme that hydrolyzes it in V. cholerae. A mutant strain defective in (p)ppGpp production (i.e.
Keywords