Proceedings of the Plant Resources Society of Korea Conference (한국자원식물학회:학술대회논문집)
- 2019.04a
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- Pages.123-123
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- 2019
Xanthone attenuates mast cell-mediated allergic inflammation
- AYE, AYE (Department of Oriental Medicine Resource, Chonbuk National University) ;
- Jeon, Yong-Deok (Department of Oriental Medicine Resource, Chonbuk National University) ;
- Song, Young-Jae (Department of Oriental Medicine Resource, Chonbuk National University) ;
- Jin, Jong-Sik (Department of Oriental Medicine Resource, Chonbuk National University)
- Published : 2019.04.25
Abstract
Xanthone is a kind of polyphenolic compounds that contain a distinctive chemical structure with a tricyclic aromatic ring found in a few higher plant families e.g. gentian root. This compound had a variety of biological activity, for instance antioxidant, antibacterial, anti-inflammatory, and anticancer effects. However, the effect of xanthone on mast cell-mediated allergic inflammation and its associated mechanism have not been elucidated. Therefore, the aim of this study was to elucidate the anti-allergic inflammatory effects and the underlying molecular mechanism of xanthone in PMACI-stimulated human mast cells-1 (HMC-1). In this result, xanthone treatment decreased the production of histamine, pro-inflammatory cytokines such as tumor necrosis factor-a (TNF-