한국자원식물학회:학술대회논문집 (Proceedings of the Plant Resources Society of Korea Conference)

한국자원식물학회 (The Plant Resources Society of Korea)
권호 표지

Inhibitory effects of Thalictrum rochebrunianum var. grandisepalum on tyrosinase in IBMX-induced B16F10 melanoma cells

  • Jang, Tae-Won (Medicinal Plant Resources, Andong National University) ;
  • Choi, Ji-Soo (Medicinal Plant Science, Jungwon University) ;
  • Mun, Jeong-Yun (Pharmaceutical Science, Jungwon University) ;
  • Im, Jong-Yun (Pharmaceutical Science, Jungwon University) ;
  • Nam, Su-Hwan (Baekdudaegan National Arboretum, Division of Education Service) ;
  • Kim, Do-Wan (Food Science, Jungwon University) ;
  • Lee, Seung-Hyun (Industry-Academic Cooperation Foundation, Jungwon University) ;
  • Park, Jae-Ho (Medicinal Plant Science, Jungwon University)
  • 발행 : 2019.04.25
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초록

Thalictrum rochebrunianum var. grandisepalum (TRG) is a Korean endemic plant, and it is widely used for edible, medicinal, landscape materials. In this study, we examined the protein and mRNA expression levels of MITF, tyrosinase, TRP-1 and TRP-2 by TRG extract (TRGE) in IBMX-treated melanocytes to evaluate the possibility of using TRG as a whitening material. IBMX were reported as melanin synthesis enhancers. It could increase intracellular melanin synthesis by activation of the microphthalmia-associated transcription factor (MITF) signaling pathway. TRGE did not show cytotoxicity at concentrations below $100{\mu}g/ml$ in B16F10 cells. TREG dose-dependently inhibited protein and mRNA levels of MITF, tyrosinase, TRP-1 and TRP-2. Therefore, we suggest that TRGE is an important natural resource for cosmetic raw materials for whitening function.

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