한국자원식물학회:학술대회논문집 (Proceedings of the Plant Resources Society of Korea Conference)
- 한국자원식물학회 2019년도 춘계학술대회
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- Pages.113-113
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- 2019
LSP로 유도된 RAW 264.7 대식세포에서 TLR4/NF-κB와 CXCL12/CXCR4 경로 억제를 통한 DATS의 항염증 효과
Anti-inflammatory effects of DATS via suppression of cross talk between the TLR4/NF-κB and CXCL12/CXCR4 pathways in LSP-stimulated RAW 264.7 macrophages
- 정용태 (국립낙동강생물자원관 동식물활용연구팀) ;
- 황병수 (국립낙동강생물자원관 동식물활용연구팀) ;
- 김민진 (국립낙동강생물자원관 동식물활용연구팀) ;
- 신수영 (국립낙동강생물자원관 동식물활용연구팀) ;
- 오영택 (국립낙동강생물자원관 동식물활용연구팀) ;
- 김철환 (국립낙동강생물자원관 동식물활용연구팀) ;
- 엄정혜 (국립낙동강생물자원관 동식물활용연구팀) ;
- 이승영 (국립낙동강생물자원관 혁신성과부) ;
- 최경민 (국립낙동강생물자원관 혁신성과부) ;
- 정진우 (국립낙동강생물자원관 동식물활용연구팀) ;
- 조표연 (국립낙동강생물자원관 동식물활용연구팀)
- Jeong, Yong Tae (Animal & Plant Utilization Team, Nakdonggang National Institute of Biological Resources) ;
- Hwang, Buyng Su (Animal & Plant Utilization Team, Nakdonggang National Institute of Biological Resources) ;
- Kim, Min-Jin (Animal & Plant Utilization Team, Nakdonggang National Institute of Biological Resources) ;
- Shin, Su Young (Animal & Plant Utilization Team, Nakdonggang National Institute of Biological Resources) ;
- Oh, Young Taek (Animal & Plant Utilization Team, Nakdonggang National Institute of Biological Resources) ;
- Kim, Chul Hwan (Animal & Plant Utilization Team, Nakdonggang National Institute of Biological Resources) ;
- Eom, Jung Hye (Animal & Plant Utilization Team, Nakdonggang National Institute of Biological Resources) ;
- Lee, Seung Young (Performance Management Division, Nakdonggang National Institute of Biological Resources) ;
- Choi, Kyung Min (Performance Management Division, Nakdonggang National Institute of Biological Resources) ;
- Jeong, Jin-Woo (Animal & Plant Utilization Team, Nakdonggang National Institute of Biological Resources) ;
- Cho, Pyo Yun (Animal & Plant Utilization Team, Nakdonggang National Institute of Biological Resources)
- 발행 : 2019.04.25
초록
Diallyl trisulfide (DATS) is an organic polysulfide compound found in garlic. Although certain studies have demonstrated that DATS possesses strong anti-inflammatory activity, the underlying molecular mechanisms remain largely unresolved. In this study, we examined whether DATS exerts anti-inflammatory activity and investigated the possible mechanisms. Our results indicated that DATS significantly suppressed the lipopolysaccharide (LPS)-induced release of nitric oxide (NO) and prostaglandin E2 by inhibiting inducible NO synthase and cyclooxygenase-2 expression at the transcriptional and post-transcriptional levels in RAW 264.7 macrophages. DATS also down-regulated Toll-like receptor 4 (TLR4) and myeloid differentiation factor 88 expression, and inhibited nuclear translocation of nuclear transcription factor-kappa B (NF-
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