Proceedings of the Plant Resources Society of Korea Conference (한국자원식물학회:학술대회논문집)
- 2018.04a
- /
- Pages.72-72
- /
- 2018
Physicochemical Characterization of Extrudate Solid Formulation of Angelica gigas Nakai Prepared by Hot Melt Extrusion Process
- Azad, Md Obyedul Kalam (College of Bio-medical Science, Kangwon National University) ;
- Cho, Hyun Jong (College of Pharmacy, Kangwon National University) ;
- Koo, Ja Seong (College of Pharmacy, Kangwon National University) ;
- Park, Cheol Ho (College of Bio-medical Science, Kangwon National University) ;
- Kang, Wie Soo (College of Bio-medical Science, Kangwon National University)
- Published : 2018.04.27
Abstract
The root of Angelica gigas Nakai (AGN) is used as a traditional herbal medicine in Korea for the treatment of many diseases. However, a major challenge associated with the usage of the active compounds from AGN is their poor water solubility. Therefore, this work aimed to enhance the solubility of active compounds by a chemical (viz. surfactant) and physical (hot melt extrusion) crosslinking method (CPC). Infrared Fourier transform spectroscopy (FT-IR) revealed multiple peaks in extrudate solids representing new functional groups including carboxylic acid, alkynes and benzene derivatives. Differential scanning calorimetry (DSC) analysis of the extrudate showed lower glass transition temperature (Tg) and lower enthalpy (
Keywords
- Bioactive herbal compounds;
- Angelica gigas Nakai;
- Nano solid dispersion;
- Size reduction;
- Hot melt extrusion