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Software development for assessing cellular heterogeneity and its clinical application in gadoxetic acid-enhanced MRI of hepatocellular carcinoma

세포 이질성 평가 소프트웨어 개발과 가도세틱산 조영증강 자기공명영상을 이용한 간세포암종 환자에의 적용

  • Kim, Tae-Hoon (Imaging Science-based Lung and Bone Disease Research Center, Wonkwang University) ;
  • Ryu, Jong-Hyun (Imaging Science-based Lung and Bone Disease Research Center, Wonkwang University) ;
  • Jeong, Chang-Won (Imaging Science-based Lung and Bone Disease Research Center, Wonkwang University) ;
  • Jun, Hong Young (Imaging Science-based Lung and Bone Disease Research Center, Wonkwang University) ;
  • Heo, Dong-Woon (Imaging Science-based Lung and Bone Disease Research Center, Wonkwang University) ;
  • Kang, Sung-Chan (Imaging Science-based Lung and Bone Disease Research Center, Wonkwang University) ;
  • Kim, Dae Won (Dept. of Neurosurgery, Wonkwang University School of Medicine) ;
  • Yoon, Kwon-Ha (Dept. of Radiology, Wonkwang University School of Medicine)
  • 김태훈 (영상의학기반 폐 및 골질환 병원특성화 영상센터, 원광대학교) ;
  • 유종현 (영상의학기반 폐 및 골질환 병원특성화 영상센터, 원광대학교) ;
  • 정창원 (영상의학기반 폐 및 골질환 병원특성화 영상센터, 원광대학교) ;
  • 전홍영 (영상의학기반 폐 및 골질환 병원특성화 영상센터, 원광대학교) ;
  • 허동운 (영상의학기반 폐 및 골질환 병원특성화 영상센터, 원광대학교) ;
  • 강성찬 (영상의학기반 폐 및 골질환 병원특성화 영상센터, 원광대학교) ;
  • 김대원 (신경외과, 원광대학교 의과대학) ;
  • 윤권하 (영상의학과, 원광대학교 의과대학)
  • Published : 2015.10.28

Abstract

In this paper, we developed the quantification software for evaluating the voxel-based cellular heterogeneity of gadoxetic acid-enhanced magnetic resonance imaging (MRI) in the liver. Our software is clinically applied to accurately quantify and interpret the alterations of liver functions in patients with hepatocellular carcinoma.

Keywords