Fabrication and characterization of aligned crossply PHBV fibrous mat

  • Kim, Yang-Hee (Department of Biomedical Engineering and Material, College of Medicine, Soonchunhyang Univ.) ;
  • Yang, Hun-Mo (Department of Physiology, College of Medicine, Soonchunhyang Univ.) ;
  • Song, Ho-Yeon (Department of Microbiology, College of Medicine, Soonchunhyang univ.) ;
  • Lee, Byong-Taek (Department of Biomedical Engineering and Materials, College of Medicine, Soonchunhyang univ.)
  • Published : 2010.05.13

Abstract

poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) is a bacterially derived copolymer produced by fermentation. PHBV has been attractive because of its potential environmental, pharmaceutical and biomedical applications. Recently, the electrospinning technique has been used to fabricate fibrous mat for biomedical applications such as artificial blood vessel, drug release and scaffolds, because this method is simple and easy to get ultrafine polymer fibers. Depending on speed of rotation drum collector, fiber structure was different. In this work, PHBV fiber was aligned by electrospinnning machine. Furthermore, alignment of PHBV fiber mats was given angle such as $45^{\circ}$, $60^{\circ}$ and $90^{\circ}$. The morphology of each aligned PHBV fiber mat was observed by SEM technique. The mechanical property was evaluated depending on alignment angle. Especially, cell attachment ability depending on alignment of PHBV fiber mats was carried out using MG- 63 osteoblast like cells.

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