Proceedings of the Korean Institute of Information and Commucation Sciences Conference (한국정보통신학회:학술대회논문집)
- 2010.10a
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- Pages.660-662
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- 2010
Inhibition of Human Cytomegalovirus Replication using Peptide Nucleic Acids with Polyethylenimine
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Eum, Jin-Seong
(Division of Bio and Health Sciences, Mokwon University)
;
- Park, Young-Doo (Division of Bio and Health Sciences, Mokwon University) ;
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Hong, Seong-Karp
(Division of Bio and Health Sciences, Mokwon University)
- Published : 2010.10.27
Abstract
To control replication of human cytomegalovirus (HCMV) effectively, inhibitors of peptide nucleic acids (PNA) with a gene delivery agent, PEI (polyethylenimine) against HCMV were applied. The transfection of these PNA inhibitors with PEI agent into host cells showed synergic inhibition effect of HCMV replication. These inhibition effect was confirmed by methods of RT-PCR, CPE, real-time-PCR, and Western blot.