Proceedings of the Materials Research Society of Korea Conference (한국재료학회:학술대회논문집)

Materials Research Society of Korea (한국재료학회)
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Reinforcement of Calcium Phosphate-Calcium Sulfate Injectable Bone Substitute Using Citric Acid and Hydroxypropyl-Methyl-Cellulose

  • Thai, Van Viet (Department of Biomedical Engineering and Materials, Shool of Medicine, Soonchunhyang University) ;
  • Kim, Min-Sung (Soonchunhyang University) ;
  • Song, Ho-Yeon (Department of Microbiology, School of Medicine, Soonchunhyang University) ;
  • Lee, Byong-Taek (Department of Biomedical Engineering and Materials, Shool of Medicine, Soonchunhyang University)
  • Published : 2009.05.21
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Abstract

In this study, we investigated a calcium phosphate-calcium sulfate injectable bone substitute (IBS) with organic reinforcement of chitosan, citric acid and hydroxypropyl-methyl-cellulose (HPMC). The powder component of IBS consisted of tetra calcium phosphate (TTCP), dicalcium phosphate dihydrate (DCPD) and calcium sulfate dihydrate (CSD). The liquid component was a solution of citric acid and chitosan. The effect of HPMC in terms of setting time, compressive strength and apatite forming ability on this IBS was investigated. The mass content of HPMC in liquid phase was varied in array of 0%, 2%, 3% and 4%. The setting times obtained between 20 and 45 minutes. Compressive strength was achieved over 20 MPa after incubation at 370C and in 100% humidity for 28 days. Porosities were evaluated in relation with compressive strength. Elastic moduli of the 28 days after-incubation IBS were obtained around 4GPa

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