Proceedings of the Materials Research Society of Korea Conference (한국재료학회:학술대회논문집)

Materials Research Society of Korea (한국재료학회)
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Simvastatin loaded porous poly(lactide-co-glycolide)(PLGA) microspheres as delivery systems strategies for injuring tissue and invitro study

  • Bao, Trinh-Quang (Department of Biomedical Engineering and Materials, College of Medicine, Soonchunhyang University) ;
  • Kim, Yang-Hee (Department of Biomedical Engineering and Materials, College of Medicine, Soonchunhyang University) ;
  • Lee, Byong-Taek (Department of Biomedical Engineering and Materials, College of Medicine, Soonchunhyang University)
  • Published : 2009.11.05
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Abstract

Regeration of natural tissuesor to create biological substitutes for defective or lost tissues and organs through the use of cells. In addition to cells and their porous, drugs are required to promote tissue regeneration. Therefore, the present studies were prepared using simvastatim loaded porous poly(lactide-co-glycolide) (PLGA) by double emulsion solvent evaporation water-in-oil-in-water technique (W/O/W) as drug delivery system strategies for injuring tissue. The resulting microspheres were evaluated for morphology, particle size, encapsulation efficiency, degradation of PLGA microspheres in vitro drug release and in vitro cell viability. Scanning electronic microscopic (SEM) showed that the porosities of the particles was changed by experimental conditions and cultured cells were attached well on porous microspheres surface. The X-ray diffraction (XRD) and differential scanning calometry (DSC) analysis indicate thatsimvastatim was highly dipersed in the microsphere at amorphousstate.

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