한국산학기술학회:학술대회논문집 (Proceedings of the KAIS Fall Conference)
- 한국산학기술학회 2009년도 추계학술발표논문집
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- Pages.318-321
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- 2009
대장내 항염증 작용이 있는 천연 소재의 개발
Studies on Protective Effect of Herbal medicines against Experimental Inflammtory Bowel Disease Model
- 조성완 (건양대학교 제약공학과)
- Cho, Seong-Wan (Dept of Pharmaceutical Engineering, Konyang University)
- 발행 : 2009.12.04
초록
The Efficacy of PSB-2061, was investigated in comparision with predinisolone in acetic acid and Picrylsulfonic acid solution (TNBS)-induced rat inflammatory bowel disease (IBD) for 5 days. 5 % TNBS solution were administered with polyethylene (P.E) tube inserted to rats intracolon, which causing colitis to the rats. The TNBS control group (the saline treated colitic rat) exhibited ulceration and inflammation of the distal colon with formation of granuloma and pathologic connections. We checked the inflammatory parameters like rat's weight, food intake quantity change during administration. After 5 days, we sacrificed the rats and checked the colon's length, ulcer and pathologic condition. Oral treatment with PSB-2061 resulted in significant recovery of macroscopic parameters like weight and diet intake change. Especially, PSB-2061 extract had a more potent effect than
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